p53 Mediates TNF-Induced Epithelial Cell Apoptosis in IBD

Chronic ulcerative colitis (CUC) is characterized by increased intestinal epithelial cell (IEC) apoptosis associated with elevated tumor necrosis factor (TNF), inducible nitric oxide synthase (iNOS), and p53. We previously showed that p53 is increased in crypt IECs in human colitis and is needed for...

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Detalhes bibliográficos
Main Authors: Goretsky, Tatiana, Dirisina, Ramanarao, Sinh, Preetika, Mittal, Navdha, Managlia, Elizabeth, Williams, David B., Posca, Daniela, Ryu, Hyunji, Katzman, Rebecca B., Barrett, Terrence A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2012
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463630/
https://ncbi.nlm.nih.gov/pubmed/22863952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.06.016
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