p53 and PUMA Independently Regulate Apoptosis of Intestinal Epithelial Cells in Patients and Mice With Colitis

BACKGROUND & AIMS: Inflammatory bowel disease (IBD) is associated with increased apoptosis of intestinal epithelial cells (IECs). Mutations in the tumor suppressor p53 appear during early stages of progression from colitis to cancer. We investigated the role of p53 and its target, p53-upregulate...

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Main Authors: DIRISINA, RAMANARAO, KATZMAN, REBECCA B., GORETSKY, TATIANA, MANAGLIA, ELIZABETH, MITTAL, NAVDHA, WILLIAMS, DAVID B., QIU, WEI, YU, JIAN, CHANDEL, NAVDEEP S., ZHANG, LIN, BARRETT, TERRENCE A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736614/
https://ncbi.nlm.nih.gov/pubmed/21699775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.05.032
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