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Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis

A common feature of inflammatory bowel disease (IBD) is the loss of intestinal epithelial barrier function due to excessive apoptosis of intestinal epithelial cells (IECs). However, the molecular mechanism underlying increased IEC apoptosis remains unclear. Here, we investigated the role of PHLPP, a...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Wen, Yang-An, Li, Xin, Goretsky, Tatiana, Weiss, Heidi L., Barrett, Terrence A., Gao, Tianyan
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4554835/
https://ncbi.nlm.nih.gov/pubmed/26187040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2015.07.012
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