Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis

A common feature of inflammatory bowel disease (IBD) is the loss of intestinal epithelial barrier function due to excessive apoptosis of intestinal epithelial cells (IECs). However, the molecular mechanism underlying increased IEC apoptosis remains unclear. Here, we investigated the role of PHLPP, a...

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Bibliographic Details
Published in:Biochim Biophys Acta
Main Authors: Wen, Yang-An, Li, Xin, Goretsky, Tatiana, Weiss, Heidi L., Barrett, Terrence A., Gao, Tianyan
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4554835/
https://ncbi.nlm.nih.gov/pubmed/26187040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2015.07.012
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