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Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis

A common feature of inflammatory bowel disease (IBD) is the loss of intestinal epithelial barrier function due to excessive apoptosis of intestinal epithelial cells (IECs). However, the molecular mechanism underlying increased IEC apoptosis remains unclear. Here, we investigated the role of PHLPP, a...

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Publicat a:Biochim Biophys Acta
Autors principals: Wen, Yang-An, Li, Xin, Goretsky, Tatiana, Weiss, Heidi L., Barrett, Terrence A., Gao, Tianyan
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4554835/
https://ncbi.nlm.nih.gov/pubmed/26187040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2015.07.012
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