Phosphoinositide 3-Kinase Signaling Mediates □-Catenin Activation in Intestinal Epithelial Stem and Progenitor Cells in Colitis

BACKGROUND & AIMS: Mechanisms responsible for crypt architectural distortion in chronic ulcerative colitis (CUC) are not well understood. Data indicate that Akt signaling cooperates with Wnt to activate β-catenin in intestinal stem and progenitor cells through phosphorylation at Ser552 (P-β-cate...

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Main Authors: Lee, Goo, Goretsky, Tatiana, Managlia, Elizabeth, Dirisina, Ramanarao, Singh, Ajay Pal, Brown, Jeffrey B, May, Randal, Yang, Guang-Yu, Ragheb, Josette William, Evers, B Mark, Weber, Christopher R., Turner, Jerrold R, He, Xi C, Katzman, Rebecca B., Li, Linheng, Barrett, Terrence A
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930080/
https://ncbi.nlm.nih.gov/pubmed/20580720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.05.037
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