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Nucleotide Excision Repair, Mismatch Repair, and R-Loops Modulate Convergent Transcription-Induced Cell Death and Repeat Instability

Expansion of CAG•CTG tracts located in specific genes is responsible for 13 human neurodegenerative disorders, the pathogenic mechanisms of which are not yet well defined. These disease genes are ubiquitously expressed in human tissues, and transcription has been identified as one of the major pathw...

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Main Authors: Lin, Yunfu, Wilson, John H.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463551/
https://ncbi.nlm.nih.gov/pubmed/23056461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046807
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