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Transcription-Induced CAG Repeat Contraction in Human Cells Is Mediated in Part by Transcription-Coupled Nucleotide Excision Repair
Expansions of CAG repeat tracts in the germ line underlie several neurological diseases. In human patients and mouse models, CAG repeat tracts display an ongoing instability in neurons, which may exacerbate disease symptoms. It is unclear how repeats are destabilized in nondividing cells, but it can...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2007
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1952160/ https://ncbi.nlm.nih.gov/pubmed/17591697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00739-07 |
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