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Transcription-Induced CAG Repeat Contraction in Human Cells Is Mediated in Part by Transcription-Coupled Nucleotide Excision Repair

Expansions of CAG repeat tracts in the germ line underlie several neurological diseases. In human patients and mouse models, CAG repeat tracts display an ongoing instability in neurons, which may exacerbate disease symptoms. It is unclear how repeats are destabilized in nondividing cells, but it can...

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Bibliografiske detaljer
Main Authors: Lin, Yunfu, Wilson, John H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952160/
https://ncbi.nlm.nih.gov/pubmed/17591697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00739-07
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