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Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability
R-loops, consisting of an RNA-DNA hybrid and displaced single-stranded DNA, are physiological structures that regulate various cellular processes occurring on chromatin. Intriguingly, changes in R-loop dynamics have also been associated with DNA damage accumulation and genome instability, however th...
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| Udgivet i: | Mol Cell |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4272638/ https://ncbi.nlm.nih.gov/pubmed/25435140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.10.020 |
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