Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage

The hormone estrogen (E2) binds the estrogen receptor to promote transcription of E2-responsive genes in the breast and other tissues. E2 also has links to genomic instability, and elevated E2 levels are tied to breast cancer. Here, we show that E2 stimulation causes a rapid, global increase in the...

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Detaylı Bibliyografya
Yayımlandı:eLife
Asıl Yazarlar: Stork, Caroline Townsend, Bocek, Michael, Crossley, Madzia P, Sollier, Julie, Sanz, Lionel A, Chédin, Frédéric, Swigut, Tomek, Cimprich, Karlene A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2016
Konular:
Genes and Chromosomes
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030092/
https://ncbi.nlm.nih.gov/pubmed/27552054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17548
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