Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage

The hormone estrogen (E2) binds the estrogen receptor to promote transcription of E2-responsive genes in the breast and other tissues. E2 also has links to genomic instability, and elevated E2 levels are tied to breast cancer. Here, we show that E2 stimulation causes a rapid, global increase in the...

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Pubblicato in:eLife
Autori principali: Stork, Caroline Townsend, Bocek, Michael, Crossley, Madzia P, Sollier, Julie, Sanz, Lionel A, Chédin, Frédéric, Swigut, Tomek, Cimprich, Karlene A
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2016
Soggetti:
Genes and Chromosomes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030092/
https://ncbi.nlm.nih.gov/pubmed/27552054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17548
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