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Genetic instability associated with loop or stem–loop structures within transcription units can be independent of nucleotide excision repair

Simple sequence repeats (SSRs) are found throughout the genome, and under some conditions can change in length over time. Germline and somatic expansions of trinucleotide repeats are associated with a series of severely disabling illnesses, including Huntington's disease. The underlying mechani...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Burns, John A, Chowdhury, Moinuddin A, Cartularo, Laura, Berens, Christian, Scicchitano, David A
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909459/
https://ncbi.nlm.nih.gov/pubmed/29474673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky110
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