A New Approach for Pyrazinamide Susceptibility Testing in Mycobacterium tuberculosis

Background: Pyrazinamide (PZA) is an important drug in the treatment of tuberculosis. Microbiological methods of PZA susceptibility testing are controversial and have low reproducibility. After conversion of PZA into pyrazinoic acid (POA) by the bacterial pyrazinamidase enzyme, the drug is expelled...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Zimic, Mirko, Loli, Sebastian, Gilman, Robert H., Gutierrez, Andrés, Fuentes, Patricia, Cotrina, Milagros, Kirwan, Daniela, Sheen, Patricia
Format: Artigo
Langue:Inglês
Publié: Mary Ann Liebert, Inc. 2012
Sujets:
Mechanisms
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462410/
https://ncbi.nlm.nih.gov/pubmed/22372927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/mdr.2011.0207
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