EFFECT OF PYRAZINAMIDASE ACTIVITY ON PYRAZINAMIDE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS

Resistance of Mycobacterium tuberculosis to pyrazinamide is associated with mutations in the pncA gene, which codes for pyrazinamidase. The association between the enzymatic activity of mutated pyrazinamidases and the level of pyrazinamide resistance remains poorly understood. Twelve M. tuberculosis...

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Main Authors: Sheen, Patricia, Ferrer, Patricia, Gilman, Robert H., López-Llano, Jon, Fuentes, Patricia, Valencia, Eddy, Zimic, Mirko J.
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691962/
https://ncbi.nlm.nih.gov/pubmed/19249243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tube.2009.01.004
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