EFFECT OF PYRAZINAMIDASE ACTIVITY ON PYRAZINAMIDE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS

Resistance of Mycobacterium tuberculosis to pyrazinamide is associated with mutations in the pncA gene, which codes for pyrazinamidase. The association between the enzymatic activity of mutated pyrazinamidases and the level of pyrazinamide resistance remains poorly understood. Twelve M. tuberculosis...

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Bibliographic Details
Main Authors: Sheen, Patricia, Ferrer, Patricia, Gilman, Robert H., López-Llano, Jon, Fuentes, Patricia, Valencia, Eddy, Zimic, Mirko J.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691962/
https://ncbi.nlm.nih.gov/pubmed/19249243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tube.2009.01.004
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