pncA gene expression and prediction factors on pyrazinamide resistance in Mycobacterium tuberculosis

BACKGROUND: Mutations in the pyrazinamidase (PZAse) coding gene, pncA, have been considered as the main cause of pyrazinamide (PZA) resistance in Mycobacterium tuberculosis. However, recent studies suggest there is no single mechanism of resistance to PZA. The pyrazinoic acid (POA) efflux rate is th...

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Autori principali: Sheen, Patricia, Lozano, Katherine, Gilman, Robert H., Valencia, Hugo J., Loli, Sebastian, Fuentes, Patricia, Grandjean, Louis, Zimic, Mirko
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755357/
https://ncbi.nlm.nih.gov/pubmed/23867321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tube.2013.03.005
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