A New Approach for Pyrazinamide Susceptibility Testing in Mycobacterium tuberculosis

Background: Pyrazinamide (PZA) is an important drug in the treatment of tuberculosis. Microbiological methods of PZA susceptibility testing are controversial and have low reproducibility. After conversion of PZA into pyrazinoic acid (POA) by the bacterial pyrazinamidase enzyme, the drug is expelled...

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Bibliographische Detailangaben
Hauptverfasser: Zimic, Mirko, Loli, Sebastian, Gilman, Robert H., Gutierrez, Andrés, Fuentes, Patricia, Cotrina, Milagros, Kirwan, Daniela, Sheen, Patricia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2012
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Mechanisms
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462410/
https://ncbi.nlm.nih.gov/pubmed/22372927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/mdr.2011.0207
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