A New Approach for Pyrazinamide Susceptibility Testing in Mycobacterium tuberculosis

Background: Pyrazinamide (PZA) is an important drug in the treatment of tuberculosis. Microbiological methods of PZA susceptibility testing are controversial and have low reproducibility. After conversion of PZA into pyrazinoic acid (POA) by the bacterial pyrazinamidase enzyme, the drug is expelled...

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Hlavní autoři: Zimic, Mirko, Loli, Sebastian, Gilman, Robert H., Gutierrez, Andrés, Fuentes, Patricia, Cotrina, Milagros, Kirwan, Daniela, Sheen, Patricia
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462410/
https://ncbi.nlm.nih.gov/pubmed/22372927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/mdr.2011.0207
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