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A New Approach for Pyrazinamide Susceptibility Testing in Mycobacterium tuberculosis

Background: Pyrazinamide (PZA) is an important drug in the treatment of tuberculosis. Microbiological methods of PZA susceptibility testing are controversial and have low reproducibility. After conversion of PZA into pyrazinoic acid (POA) by the bacterial pyrazinamidase enzyme, the drug is expelled...

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Detalhes bibliográficos
Main Authors: Zimic, Mirko, Loli, Sebastian, Gilman, Robert H., Gutierrez, Andrés, Fuentes, Patricia, Cotrina, Milagros, Kirwan, Daniela, Sheen, Patricia
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462410/
https://ncbi.nlm.nih.gov/pubmed/22372927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/mdr.2011.0207
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