A New Approach for Pyrazinamide Susceptibility Testing in Mycobacterium tuberculosis

Background: Pyrazinamide (PZA) is an important drug in the treatment of tuberculosis. Microbiological methods of PZA susceptibility testing are controversial and have low reproducibility. After conversion of PZA into pyrazinoic acid (POA) by the bacterial pyrazinamidase enzyme, the drug is expelled...

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Bibliografske podrobnosti
Main Authors: Zimic, Mirko, Loli, Sebastian, Gilman, Robert H., Gutierrez, Andrés, Fuentes, Patricia, Cotrina, Milagros, Kirwan, Daniela, Sheen, Patricia
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc. 2012
Teme:
Mechanisms
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462410/
https://ncbi.nlm.nih.gov/pubmed/22372927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/mdr.2011.0207
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