Familial Parkinson's disease iPSCs show cellular deficits in mitochondrial responses that can be pharmacologically rescued

Parkinson's disease (PD) is a common neurodegenerative disease caused by genetic and environmental factors. We analyzed induced pluripotent stem cell (iPSC)-derived neural cells from PD patients and presymptomatic individuals carrying mutations in the PINK1 and LRRK2 genes, and healthy control...

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Autori principali: Cooper, Oliver, Seo, Hyemyung, Andrabi, Shaida, Guardia-Laguarta, Cristina, Graziotto, John, Sundberg, Maria, McLean, Jesse R., Carrillo-Reid, Luis, Xie, Zhong, Osborn, Teresia, Hargus, Gunnar, Deleidi, Michela, Lawson, Tristan, Bogetofte, Helle, Perez-Torres, Eduardo, Clark, Lorraine, Moskowitz, Carol, Mazzulli, Joseph, Chen, Li, Volpicelli-Daley, Laura, Romero, Norma, Jiang, Houbo, Uitti, Ryan J., Huang, Zhigao, Opala, Grzegorz, Scarffe, Leslie A., Dawson, Valina L., Klein, Christine, Feng, Jian, Ross, Owen A., Trojanowski, John Q., Lee, Virginia M.-Y., Marder, Karen, Surmeier, D. James, Wszolek, Zbigniew K., Przedborski, Serge, Krainc, Dimitri, Dawson, Ted M., Isacson, Ole
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462009/
https://ncbi.nlm.nih.gov/pubmed/22764206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3003985
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