IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

Alcoholic liver disease (ALD) is characterized by steatosis and upregulation of proinflammatory cytokines, including IL-1β. IL-1β, type I IL-1 receptor (IL-1R1), and IL-1 receptor antagonist (IL-1Ra) are all important regulators of the IL-1 signaling complex, which plays a role in inflammation. Furt...

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Main Authors: Petrasek, Jan, Bala, Shashi, Csak, Timea, Lippai, Dora, Kodys, Karen, Menashy, Victoria, Barrieau, Matthew, Min, So-Yun, Kurt-Jones, Evelyn A., Szabo, Gyongyi
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461900/
https://ncbi.nlm.nih.gov/pubmed/22945633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60777
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