Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis

BACKGROUND & AIMS: Inflammation promotes the progression of non-alcoholic steatohepatitis (NASH). Toll-like receptor 4 (TLR4) and TLR9 activation through myeloid differentiation primary response gene 88 (MyD88) and production of mature interleukin-1β (IL-1β) via inflammasome activation contribut...

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Autori principali: Csak, Timea, Pillai, Arun, Ganz, Michal, Lippai, Dora, Petrasek, Jan, Park, Jin-Kyu, Kodys, Karen, Dolganiuc, Angela, Kurt-Jones, Evelyn A., Szabo, Gyongyi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169310/
https://ncbi.nlm.nih.gov/pubmed/24650018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/liv.12537
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