microRNA-122 regulates hypoxia-inducible factor-1 and vimentin in hepatocytes and correlates with fibrosis in diet-induced steatohepatitis

BACKGROUND & AIMS: miR-122 is the most abundant miRNA in the liver particularly in hepatocytes where it targets cholesterol metabolism. Steatosis, a key component of non-alcoholic fatty liver disease , is regulated by hypoxia-inducible factor-1α (HIF-1α). Here, we hypothesized that reduced miR-1...

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發表在:Liver Int
Main Authors: Csak, Timea, Bala, Shashi, Lippai, Dora, Satishchandran, Abishek, Catalano, Donna, Kodys, Karen, Szabo, Gyongyi
格式: Artigo
語言:Inglês
出版: 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289469/
https://ncbi.nlm.nih.gov/pubmed/25040043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/liv.12633
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