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microRNA-122 regulates hypoxia-inducible factor-1 and vimentin in hepatocytes and correlates with fibrosis in diet-induced steatohepatitis
BACKGROUND & AIMS: miR-122 is the most abundant miRNA in the liver particularly in hepatocytes where it targets cholesterol metabolism. Steatosis, a key component of non-alcoholic fatty liver disease , is regulated by hypoxia-inducible factor-1α (HIF-1α). Here, we hypothesized that reduced miR-1...
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| Veröffentlicht in: | Liver Int |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4289469/ https://ncbi.nlm.nih.gov/pubmed/25040043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/liv.12633 |
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