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Coordinated Activities of Human Dicer Domains in Regulatory RNA Processing

The conserved ribonuclease Dicer generates microRNAs and short interfering RNAs that guide gene silencing in eukaryotes. The specific contributions of human Dicer's structural domains to RNA product length and substrate preference are incompletely understood, due in part to the difficulties of...

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Detalles Bibliográficos
Main Authors: Ma, Enbo, Zhou, Kaihong, Kidwell, Mary Anne, Doudna, Jennifer A.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461841/
https://ncbi.nlm.nih.gov/pubmed/22727743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.06.009
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