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Coordinated Activities of Human Dicer Domains in Regulatory RNA Processing

The conserved ribonuclease Dicer generates microRNAs and short interfering RNAs that guide gene silencing in eukaryotes. The specific contributions of human Dicer's structural domains to RNA product length and substrate preference are incompletely understood, due in part to the difficulties of...

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Détails bibliographiques
Auteurs principaux: Ma, Enbo, Zhou, Kaihong, Kidwell, Mary Anne, Doudna, Jennifer A.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461841/
https://ncbi.nlm.nih.gov/pubmed/22727743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.06.009
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