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Corruption and Spread of Pathogenic Proteins in Neurodegenerative Diseases

With advancing age, the brain becomes increasingly susceptible to neurodegenerative diseases, most of which are characterized by the misfolding and errant aggregation of certain proteins. The induction of aggregation involves a crystallization-like seeding mechanism by which a specific protein is st...

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Detalhes bibliográficos
Main Authors: Walker, Lary C., LeVine, Harry
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460416/
https://ncbi.nlm.nih.gov/pubmed/22879600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R112.399378
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