Transcellular Targeting of Fiber- and Hexon-Modified Adenovirus Vectors across the Brain Microvascular Endothelial Cells In Vitro

In central nervous system (CNS)-directed gene therapy, efficient targeting of brain parenchyma through the vascular route is prevented by the endothelium and the epithelium of the blood-brain and the blood-cerebrospinal fluid barriers, respectively. In this study, we evaluated the feasibility of the...

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Autores principales: Laakkonen, Johanna P., Engler, Tatjana, Romero, Ignacio A., Weksler, Babette, Couraud, Pierre-Olivier, Kreppel, Florian, Kochanek, Stefan
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459940/
https://ncbi.nlm.nih.gov/pubmed/23029348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045977
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