miRNA-mediated Silencing in Hepatocytes Can Increase Adaptive Immune Responses to Adenovirus Vector-delivered Transgenic Antigens

Adenovirus vectors based on human serotype 5 can induce potent CD8 T cell responses to vector-encoded transgenic antigens. However, the individual contribution of different cell types expressing antigen upon adenovirus vector injection to the generation of antigen-directed adaptive immune responses...

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Bibliographic Details
Main Authors: Kron, Matthias W, Espenlaub, Sigrid, Engler, Tatjana, Schirmbeck, Reinhold, Kochanek, Stefan, Kreppel, Florian
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2011
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149177/
https://ncbi.nlm.nih.gov/pubmed/21556053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.83
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