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Long-Term Transgene Expression in Proliferating Cells Mediated by Episomally Maintained High-Capacity Adenovirus Vectors

High-capacity “gutless” adenovirus vectors (HC-AdV) mediate long-term transgene expression in resting cells in vitro and in vivo because of low toxicity and immunogenicity. However, in proliferating cells, expression is transient since HC-AdV genomes do not possess elements that allow for replicatio...

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Bibliografische gegevens
Hoofdauteurs: Kreppel, Florian, Kochanek, Stefan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2004
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC303378/
https://ncbi.nlm.nih.gov/pubmed/14671083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.1.9-22.2004
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