Modifications of Adenovirus Hexon Allow for Either Hepatocyte Detargeting or Targeting With Potential Evasion From Kupffer Cells

In vivo gene transfer with adenovirus vectors would significantly benefit from a tight control of the adenovirus-inherent liver tropism. For efficient hepatocyte transduction, adenovirus vectors need to evade from Kupffer cell scavenging while delivery to peripheral tissues or tumors could be improv...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Prill, Jan-Michael, Espenlaub, Sigrid, Samen, Ulrike, Engler, Tatjana, Schmidt, Erika, Vetrini, Francesco, Rosewell, Amanda, Grove, Nathan, Palmer, Donna, Ng, Philip, Kochanek, Stefan, Kreppel, Florian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2011
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017454/
https://ncbi.nlm.nih.gov/pubmed/20959811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.229
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