Identification of thymidine-5′-aldehyde at DNA strand breaks induced by neocarzinostatin chromophore

Snake venom phosphodiesterase or endonuclease S1 digestion of neocarzinostatin chromophore-treated DNA, labeled in its thymidine residues, liberates an unusual labeled nucleoside from the 5′ end of a drug-induced break. This substance, isolated by reverse-phase HPLC, possesses carbons from both the...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Kappen, Lizzy S., Goldberg, Irving H., Liesch, Jerrold M.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1982
Sujets:	Biological Sciences: Biochemistry
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC345828/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/16593156/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.3.744
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