Nucleic acid-binding molecules with high affinity and base sequence specificity: intercalating agents covalently linked to oligodeoxynucleotides.

Oligodeoxyribonucleotides covalently linked to an intercalating agent via a polymethylene linker were synthesized. Oligothymidylates attached to an acridine dye (Acr) through the 3'-phosphate group [(Tp)n(CH2) mAcr ] specifically interact with the complementary sequence. The interaction is strongly...

Description complète

Détails bibliographiques

Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Asseline, U, Delarue, M, Lancelot, G, Toulmé, F, Thuong, N T, Montenay-Garestier, T, Hélène, C
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1984
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC345494/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6587350/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.11.3297
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!