Nucleic acid-binding molecules with high affinity and base sequence specificity: intercalating agents covalently linked to oligodeoxynucleotides.

Oligodeoxyribonucleotides covalently linked to an intercalating agent via a polymethylene linker were synthesized. Oligothymidylates attached to an acridine dye (Acr) through the 3'-phosphate group [(Tp)n(CH2) mAcr ] specifically interact with the complementary sequence. The interaction is strongly...

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Εκδόθηκε σε:	Proc Natl Acad Sci U S A
Κύριοι συγγραφείς:	Asseline, U, Delarue, M, Lancelot, G, Toulmé, F, Thuong, N T, Montenay-Garestier, T, Hélène, C
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	National Academy of Sciences 1984
Θέματα:	Research Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC345494/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6587350/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.11.3297
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