Sequence-specific intercalating agents: intercalation at specific sequences on duplex DNA via major groove recognition by oligonucleotide-intercalator conjugates.

An acridine derivative was covalently linked to the 5' end of a homopyrimidine oligonucleotide. Specific binding to a homopurine-homopyrimidine sequence of duplex DNA was demonstrated by spectroscopic studies (absorption and fluorescence) and by "footprinting" experiments with a coppe...

Full description

Saved in:
Bibliographic Details
Main Authors: Sun, J S, François, J C, Montenay-Garestier, T, Saison-Behmoaras, T, Roig, V, Thuong, N T, Hélène, C
Format: Artigo
Language:Inglês
Published: 1989
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC298461/
https://ncbi.nlm.nih.gov/pubmed/2594761
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items