Sequence-specific intercalating agents: intercalation at specific sequences on duplex DNA via major groove recognition by oligonucleotide-intercalator conjugates.

An acridine derivative was covalently linked to the 5' end of a homopyrimidine oligonucleotide. Specific binding to a homopurine-homopyrimidine sequence of duplex DNA was demonstrated by spectroscopic studies (absorption and fluorescence) and by "footprinting" experiments with a copper phenanthrolin...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Sun, J S, François, J C, Montenay-Garestier, T, Saison-Behmoaras, T, Roig, V, Thuong, N T, Hélène, C
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1989
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298461/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2594761/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.23.9198
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