Triple helix formation with purine-rich phosphorothioate-containing oligonucleotides covalently linked to an acridine derivative.

Purine-rich (GA)- and (GT)-containing oligophosphorothioates were investigated for their triplex-forming potential on a 23 bp DNA duplex target. In our system, GA-containing oligophosphorothioates (23mer GA-PS) were capable of triplex formation with binding affinities lower than (GA)-containing olig...

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Autors principals: Lacoste, J, François, J C, Hélène, C
Format: Artigo
Idioma:Inglês
Publicat: 1997
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC146674/
https://ncbi.nlm.nih.gov/pubmed/9115367
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