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Triple helix formation with purine-rich phosphorothioate-containing oligonucleotides covalently linked to an acridine derivative.

Purine-rich (GA)- and (GT)-containing oligophosphorothioates were investigated for their triplex-forming potential on a 23 bp DNA duplex target. In our system, GA-containing oligophosphorothioates (23mer GA-PS) were capable of triplex formation with binding affinities lower than (GA)-containing olig...

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Udgivet i:Nucleic Acids Res
Principais autores: Lacoste, J, François, J C, Hélène, C
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146674/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9115367/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.10.1991
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