Sequence-specific photo-induced cross-linking of the two strands of double-helical DNA by a psoralen covalently linked to a triple helix-forming oligonucleotide.

On the basis of the structure of DNA-psoralen bis adducts (formed by psoralen with two thymines on opposite strands), a psoralen-oligonucleotide conjugate was designed to photoinduce a cross-link between the two DNA strands at a specific sequence. Psoralen was attached via its C-5 position to a 5�...

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Bibliographic Details
Main Authors: Takasugi, M, Guendouz, A, Chassignol, M, Decout, J L, Lhomme, J, Thuong, N T, Hélène, C
Format: Artigo
Language:Inglês
Published: 1991
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC51925/
https://ncbi.nlm.nih.gov/pubmed/2062839
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