Sequence-specific intercalating agents: intercalation at specific sequences on duplex DNA via major groove recognition by oligonucleotide-intercalator conjugates.

An acridine derivative was covalently linked to the 5' end of a homopyrimidine oligonucleotide. Specific binding to a homopurine-homopyrimidine sequence of duplex DNA was demonstrated by spectroscopic studies (absorption and fluorescence) and by "footprinting" experiments with a coppe...

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Autors principals: Sun, J S, François, J C, Montenay-Garestier, T, Saison-Behmoaras, T, Roig, V, Thuong, N T, Hélène, C
Format: Artigo
Idioma:Inglês
Publicat: 1989
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC298461/
https://ncbi.nlm.nih.gov/pubmed/2594761
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