Lower Than Expected Maraviroc Concentrations in Cerebrospinal Fluid Exceed the Wild-Type CCR5-tropic HIV-1 50% Inhibitory Concentration

OBJECTIVES: to measure maraviroc total cerebrospinal fluid (CSF) concentrations and compare them with total and unbound plasma concentrations. METHODS: Total maraviroc was measured by reverse phase high performance liquid chromatography with tandem mass spectrometry while ultrafiltration was used fo...

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Bibliografiske detaljer
Main Authors: CROTEAU, David, BEST, Brookie M., LETENDRE, Scott, ROSSI, Steven S., ELLIS, Ronald J., CLIFFORD, David B., COLLIER, Ann C., GELMAN, Benjamin B., MCARTHUR, Justin C., MCCUTCHAN, J. Allen, MORGELLO, Susan, GRANT, Igor
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3454507/
https://ncbi.nlm.nih.gov/pubmed/22313954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e328351f627
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