Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins

Cancer cells are hypersensitive to nutrient limitation because oncogenes constitutively drive glycolytic and tricarboxylic acid (TCA) cycle intermediates into biosynthetic pathways. Because the anaplerotic reactions that replace these intermediates are fueled by imported nutrients, the cancer cell’s...

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Bibliographische Detailangaben
Hauptverfasser: Rosales, Kimberly Romero, Singh, Gurpreet, Wu, Kevin, Chen, Jie, Janes, Matthew R., Lilly, Michael B., Peralta, Eigen R., Siskind, Leah J., Bennett, Michael J., Fruman, David A., Edinger, Aimee L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3454501/
https://ncbi.nlm.nih.gov/pubmed/21767261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20110853
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