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Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins
Cancer cells are hypersensitive to nutrient limitation because oncogenes constitutively drive glycolytic and tricarboxylic acid (TCA) cycle intermediates into biosynthetic pathways. Because the anaplerotic reactions that replace these intermediates are fueled by imported nutrients, the cancer cell’s...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3454501/ https://ncbi.nlm.nih.gov/pubmed/21767261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20110853 |
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