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Rab7 Activation by Growth Factor Withdrawal Contributes to the Induction of Apoptosis

The Rab7 GTPase promotes membrane fusion reactions between late endosomes and lysosomes. In previous studies, we demonstrated that Rab7 inactivation blocks growth factor withdrawal-induced cell death. These results led us to hypothesize that growth factor withdrawal activates Rab7. Here, we show tha...

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Detalhes bibliográficos
Main Authors: Romero Rosales, Kimberly, Peralta, Eigen R., Guenther, Garret G., Wong, Susan Y., Edinger, Aimee L.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695791/
https://ncbi.nlm.nih.gov/pubmed/19386765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-09-0911
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