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B Cell Rab7 Mediates Induction of AID Expression and Class-Switching in T-dependent and T-independent Antibody Responses
Class switch DNA recombination (CSR) is central to the maturation of the antibody response, as it diversifies antibody effector functions. Like somatic hypermutation, CSR requires AID, whose expression is restricted to B cells, as induced by CD40 engagement or dual TLR-BCR engagement (primary CSR-in...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4643723/ https://ncbi.nlm.nih.gov/pubmed/25740947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401896 |
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