Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins

Cancer cells are hypersensitive to nutrient limitation because oncogenes constitutively drive glycolytic and tricarboxylic acid (TCA) cycle intermediates into biosynthetic pathways. Because the anaplerotic reactions that replace these intermediates are fueled by imported nutrients, the cancer cell’s...

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Main Authors: Rosales, Kimberly Romero, Singh, Gurpreet, Wu, Kevin, Chen, Jie, Janes, Matthew R., Lilly, Michael B., Peralta, Eigen R., Siskind, Leah J., Bennett, Michael J., Fruman, David A., Edinger, Aimee L.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3454501/
https://ncbi.nlm.nih.gov/pubmed/21767261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20110853
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