TARGETING STAT3 ABROGATES EGFR INHIBITOR RESISTANCE IN CANCER

PURPOSE: EGFR is upregulated in most epithelial cancers where signaling through EGFR contributes to cancer cell proliferation and survival. The limited clinical efficacy of EGFR inhibitors suggests that identification of resistance mechanisms may identify new pathways for therapeutic targeting. Sign...

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Main Authors: Sen, Malabika, Joyce, Sonali, Panahandeh, Mary, Li, Changyou, Thomas, Sufi M., Maxwell, Jessica, Wang, Lin, Gooding, William E., Johnson, Daniel E., Grandis, Jennifer R.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3445706/
https://ncbi.nlm.nih.gov/pubmed/22825581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0792
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