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Sodium cantharidate targets STAT3 and abrogates EGFR inhibitor resistance in osteosarcoma
Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. Overactive EGFR signaling is frequently seen in osteosarcoma cells, and represents a potential therapeutic target. However, feedback activation of STAT3 after EGFR inhibition is linked to treatment resistance,...
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| Published in: | Aging (Albany NY) |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Impact Journals
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6710037/ https://ncbi.nlm.nih.gov/pubmed/31422383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102193 |
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