Overcoming resistance of targeted EGFR monotherapy by inhibition of STAT3 escape pathway in soft tissue sarcoma

Although epidermal growth factor receptor (EGFR) is often over-expressed in soft tissue sarcoma (STS), a phase II trial using an EGFR inhibitor gefitinib showed a low response rate. This study identified a new secondary resistance mechanism of gefitinib in STS, and developed new strategies to improv...

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Опубликовано в: :Oncotarget
Главные авторы: Wang, Xiaochun, Goldstein, David, Crowe, Philip J., Yang, Mark, Garrett, Kerryn, Zeps, Nikolajs, Yang, Jia-Lin
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2016
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008301/
https://ncbi.nlm.nih.gov/pubmed/26909593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7452
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