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Dimerization and the effectiveness of ICAM-1 in mediating LFA-1-dependent adhesion

Dimeric intercellular adhesion molecule-1 (ICAM-1) binds more efficiently to lymphocyte function-associated antigen-1 (LFA-1) than monomeric ICAM-1. However, it is unknown whether dimerization enhances binding simply by providing two ligand-binding sites and thereby increasing avidity, or whether it...

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Tallennettuna:
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Jun, Chang-Duk, Shimaoka, Motomu, Carman, Christopher V., Takagi, Junichi, Springer, Timothy A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2001
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC34438/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11391003/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.121186998
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