Dimerization and the effectiveness of ICAM-1 in mediating LFA-1-dependent adhesion

Dimeric intercellular adhesion molecule-1 (ICAM-1) binds more efficiently to lymphocyte function-associated antigen-1 (LFA-1) than monomeric ICAM-1. However, it is unknown whether dimerization enhances binding simply by providing two ligand-binding sites and thereby increasing avidity, or whether it...

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Main Authors: Jun, Chang-Duk, Shimaoka, Motomu, Carman, Christopher V., Takagi, Junichi, Springer, Timothy A.
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 2001
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC34438/
https://ncbi.nlm.nih.gov/pubmed/11391003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.121186998
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