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Gain-of-function analogs of the pore-forming peptide melittin selected by orthogonal high-throughput screening
We recently developed an orthogonal, high-throughput assay to identify peptides that self-assemble into potent, equilibrium pores in synthetic lipid bilayers. Here, we use this assay as a high-throughput screen to select for highly potent pore-forming peptides from a 7,776-member rational combinator...
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| Główni autorzy: | , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3443472/ https://ncbi.nlm.nih.gov/pubmed/22731650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3042004 |
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