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Synthetic molecular evolution of pore–forming peptides by Iterative combinatorial library screening

We previously reported the de novo design of a combinatorial peptide library that was subjected to high–throughput screening to identify membrane permeabilizing antimicrobial peptides that have β–sheet–like secondary structure. Those peptides do not form discreet pores in membranes but instead parti...

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Hlavní autoři: Krauson, Aram J., He, Jing, Wimley, Andrew W., Hoffmann, Andrew R., Wimley, William C
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644507/
https://ncbi.nlm.nih.gov/pubmed/23394375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300598k
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