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Synthetic molecular evolution of pore–forming peptides by Iterative combinatorial library screening

We previously reported the de novo design of a combinatorial peptide library that was subjected to high–throughput screening to identify membrane permeabilizing antimicrobial peptides that have β–sheet–like secondary structure. Those peptides do not form discreet pores in membranes but instead parti...

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Detalles Bibliográficos
Main Authors: Krauson, Aram J., He, Jing, Wimley, Andrew W., Hoffmann, Andrew R., Wimley, William C
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644507/
https://ncbi.nlm.nih.gov/pubmed/23394375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300598k
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