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β-Sheet Pore-Forming Peptides Selected from a Rational Combinatorial Library: Mechanism of Pore Formation in Lipid Vesicles and Activity in Biological Membranes

In a previous report we described the selection of potent, β-sheet pore-forming peptides from a combinatorial library designed to mimic membrane-spanning β-hairpins (Rausch JM, Marks JR and Wimley WC, (2005) PNAS, 102:10511-5). Here, we characterize their mechanism of action and compare the structur...

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Bibliografiske detaljer
Main Authors: Rausch, Joshua M., Marks, Jessica R., Rathinakumar, Ramesh, Wimley, William C.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583027/
https://ncbi.nlm.nih.gov/pubmed/17918962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi700978h
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